Researchers at the University of Edinburgh have found genetic differences in people with ME/CFS.
The discovery supports a biological cause and challenges the belief that the illness is psychological. The team studied DNA from 275,488 people, including 15,579 who reported ME/CFS symptoms.
Several gene variants appeared more often in those with the condition. These genes relate to the immune system, nervous system, and how the body responds to infection. One gene variant also links to chronic pain, a common ME/CFS symptom.
This marks the first strong genetic evidence for ME/CFS. The findings support what patients have said for years. While the study does not lead to a cure, it opens the door to future research and better understanding.
Experts note that the study relied on self-reported cases. They say larger studies using diagnosed samples are needed. Turning these findings into treatments will also require major funding and long-term effort.“These results reflect patient experience and could change ME/CFS research,” said researcher Andy Devereux-Cooke.